With "low-altitude airspace" as its core carrier, the low-altitude economy profoundly reshapes the governance paradigm and operational logic of modern cities through spatial adaptation, expanding new spaces and enhancing new driving forces for the construction of resilient and safe cities. Currently, the construction of resilient and safe cities driven by the low-altitude economy faces spatial resource mismatch challenges such as institutional fragmentation, technological shortcomings, safety risks, industrial dispersion, and governance deficits. To drive the construction of resilient and safe cities with the low-altitude economy, we should be guided by institutional resilience, supported by technological resilience, with industrial resilience as the core, and social resilience as the foundation. We should continuously optimize the ternary balance of "safety-resilience-benefits", accelerate the construction of a new spatial coordination pattern featuring multi-party co-governance among city governments, markets, and society, and provide a powerful driving engine and solid support for the construction of modern people-oriented cities.