The construction of digital economy networks has injected new momentum into the development of a unified national market and has become a critical foundation for smoothing domestic economic circulation. Using city-level data from 2011-2020，from the perspective of network centrality， this study systematically examines how a city’s position within the digital economy network influences its regional market potential. The results show that enhancing a city’s degree centrality in the digital economy network significantly boosts its regional market potential， a finding that remains robust after a series of robustness tests. This effect is primarily driven by the strengthening of market integration and technology spillover effects. Moreover， the facilitating effect exhibits no significant gradient differences across geographical regions or city types， indicating strong generalizability. Based on these findings， policy recommendations are proposed to optimize urban network positioning， jointly unlock domestic market potential， and accelerate the construction of a leading digital nation.